A new technological advance has lead to a master/slave relationship between humans and the Licker-type BOW, though over time the human host gives way to the virus inside him.
Leon Kennedy (voiced by Matthew Mercer) is in the country, despite being told to evacuate along with every other American citizen, and finds himself in the epicenter of an outbreak of BOWs (Bio-Organic Weapons, which we know as the various forms of infected).
This film takes place in the Eastern Slav Republic, a newfound country that split off from Russia, which is in the midst of its own miniature civil war. This sequel is a definite change in tone from 'Degeneration,' and for the better. While I enjoyed the first CG film, I doubted it did well enough to spur a second film.and apparently I was wrong, as in less than two years, 'Degeneration' sold over 1.6 million discs, and the same month those figures were announced, so was 'Damnation.' For those who have not been keeping track, the CG 'Resident Evil' films ( 'Degeneration' and now 'Damnation') take place in the same universe/timeline as the video game series, with 'Damnation' being a pre-cursor or tie-in to 'Resident Evil 6.' The live action films, starring the stunning Milla Jovovich, are not considered canon, taking place in an alternate timeline of some sort, featuring the same characters, but with different consequences.